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. 2017 Feb 14;8:39. doi: 10.3389/fneur.2017.00039

Figure 2.

Figure 2

(A) Brain water content (BWC) (means ± SEM) at 48 h post-injury in naïve animals, sham-injured controls and animals subjected to the midline fluid percussion brain injury (mFPI) treated with active compound [antisecretory factor (AF)-16] or inactive control substance (scramble). The brain regions underlying the impact were split into two halves. In the caudal brain regions, the mFPI induced a significant (*) increase in BWC compared to all other groups, except the sham-injured scramble-treated group (p = 0.11). Treatment with AF-16 following mFPI attenuated the increase in BWC compared to brain-injured, scramble-treated group (#p < 0.05). (B,C) Memory (probe) trial performed 48 h after sham- or midline fluid percussion injury (mFPI) and in naïve controls. Graphs showing the results from the first 30 s of the memory test in the short-term experiments (means ± SEM). The animals were treated with intranasal administration of either active compound (AF-16) or inactive control substance (Scramble). The latency to locate the platform area did not differ among the different treatment groups (B), neither did the time spent in the platform quadrant (C).