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. 2017 Feb 14;11:28. doi: 10.3389/fncel.2017.00028

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Copyright © 2017 Nikitin, Bal, Malyshev, Ierusalimsky, Spivak, Balaban and Volgushev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parallels in the age-dependent improvement of encoding of high frequencies in neurons in slices and in cultures. (A) Averaged transfer functions for two groups of neurons in slices prepared from 9 to 13 day old rats (cyan, N = 13) and 17–25 day old animals (magenta, N = 12). For comparison, transfer functions for three age groups of cultured neurons are shown (gray; 11–15 day; 16–20 day and 21–25 day; data from Figure 3B). (B,C) Correlation between attenuation of encoding of high frequencies (B: 100 Hz/13 Hz; C: 230 Hz/13 Hz) and age for slice neurons (red diamond symbols, B: r = 0.35, p = 0.056; C: r = 0.72, p < 0.001) or days in culture for cultured neurons (lilac circles, B: r = 0.72, p < 0.001; C: r = 0.63, p < 0.001). (D,E) Correlation between attenuation of encoding of high frequencies (D: 100 Hz/13 Hz; E: 230 Hz/13 Hz) and input resistance for neurons in slices (red diamonds, D: r = −0.41, p = 0.022; E: r = −0.62, p < 0.001) and in cultures (lilac circles, D: r = −0.71, p < 0.001; E: r = −0.45, p = 0.013). (F,G) Correlation between attenuation of encoding of high frequencies (F: 100 Hz/13 Hz; G: 230 Hz/13 Hz) and AP onset rapidness for neurons in slices (red diamonds, F: r = 0.28, p = 0.12; G: r = 0.72, p < 0.001) and in cultures (lilac circles, F: r = 0.71, p < 0.001; G: r = 0.54, p = 0.002). (H,I) Correlation between attenuation of encoding of high frequencies (H: 100 Hz/13 Hz; I: 230 Hz/13 Hz) and the ratio of errors of exponential to linear fits for neurons in slices (red diamonds, H: r = 0.55, p = 0.001; I: r = 0.75, p < 0.001) and in cultures (lilac circles, H: r = 0.69, p < 0.001; I: r = 0.53, p = 0.003).