Table 1.

Serum MMP-2 and MMP-9 levels and tissue MMP-9 reactivity in glioma patients

Case	Sex	Age	Diagnosis	Localization	WHO Grade	Serum MMPs (vol × 10−3)				Tissue MMP-9
						MMP-9 (240 kDa)	MMP-9 (130 kDa)	MMP-9 (92 kDa)	MMP-2 (72 kDa)	Neoplastic vessels	Neoplastic glial cells
1	M	43	A	Cerebellum	I	nd	nd	243	574	0	0
2	F	17	A	Encephalon	I	207	415	1482	249	0	0
3	M	39	G	Cerebellum	I	106	50	1243	576	0	0
4	F	32	O	Left temporal lobe	II	248	113	1765	942	0	+++
5	M	40	O	Left frontal lobe	II	62	58	1051	547	0	+++
6	M	49	AO	Right frontal lobe	III	103	123	1262	410	0	+++
7	F	82	AO	Right temporal lobe	III	342	214	1684	893	0	++
8	F	73	AO	Left frontal lobe	III	185	102	1262	359	0	++
9	M	73	AO	Encephalon	III	110	61	708	310	0	++
10	M	68	GMB	Left temporal lobe	IV	88	38	1015	460	++	0
11	M	56	GMB	Left temporal lobe	IV	111	115	1394	493	++	++
12	M	48	GMB	Left frontal lobe	IV	47	nd	667	464	+++	+
13	M	62	GMB	Right temporal lobe	IV	140	nd	1190	566	++	+
14	F	76	GMB	Right parietal lobe	IV	82	61	892	540	++	++
15	M	77	GMB	Encephalon	IV	117	nd	1096	392	Not done	Not done
16	M	75	GMB	Right parietal lobe	IV	194	96	1408	205	Not done	Not done
17	M	58	GMB	Left temporal lobe	IV	203	nd	1361	1026	0	+
18	F	63	GMB	Right temporal lobe	IV	101	nd	1130	526	++	++
19	M	78	GMB	Right temporal lobe	IV	162	61	470	70	0	+
20	F	45	GMB	Left frontal lobe	IV	77	nd	1117	308	Not done	Not done

A astrocytoma, G ganglioglioma, O oligodendroglioma, AO anaplastic oligodendroglioma, GMB glioblastoma multiforme, MMP matrix-metalloproteinase, nd not detectable, 0 no signal, + <10 %, ++ 10–30 %, +++ 30 %