This study shows the benefit of the population approach to describe pharmacokinetics in non-clinical studies of ophthalmic drugs after topical administration. The pharmacokinetics modeling is a particularly added value to provide tailored answers with sparse data.

To improve the predictive performance of the models, sampling protocol must be optimized. When data are available, this approach could allow the prediction of drug concentrations in the target tissue (eye substructure) and the evaluation of drug efficacy.