Table 2.
Comparison of pharmacokinetic parameters of clopidogrel (CLP) and its metabolites according to CYP3A4*1G status. CYP cytochrome P450
| Pharmacokinetic parameter | wt/wt | wt/*1G | p |
|---|---|---|---|
| CLP | n = 32 | n = 6 | |
| AUC0–t (ng·h/mL) | 3.88 (2.23–7.80) | 4.42 (2.51–6.86) | 0.979 |
| C max (ng/mL) | 1.37 (0.61–2.42) | 1.60 (1.03–2.09) | 0.761 |
| T max (h) | 1.00 (0.50–2.00) | 1.00 (0.50–2.00) | 0.699 |
| t 1/2 (h) | 1.15 (0.72–2.33) | 1.20 (0.76–1.96) | 0.816 |
| Cl (L/h) | 15,607 (8657–22,846) | 14,365 (8694–26,772) | 0.979 |
| V d (L) | 34,652 (13,840–69,963) | 28,763 (21,447–35,866) | 0.897 |
| CLPM | n = 35 | n = 9 | |
| AUC0–t (ng·h/mL) | 10,137 (6998–12,135) | 7712 (7012–8118) | 0.282 |
| C max (ng/mL) | 1952 (1449–2802) | 2560 (2116–3512) | 0.171 |
| T max (h) | 1.00 (0.75–2.00) | 1.00 (0.50–2.00) | 0.692 |
| t 1/2 (h) | 7.19 (5.13–9.31) | 6.55 (3.42–8.56) | 0.602 |
| H3 | n = 23 | n = 6 | |
| AUC0–t (ng·h/mL) | 5.69 (3.27–7.69) | 5.70 (1.68–10.14) | 0.417 |
| C max (ng/mL) | 3.41 (1.97–5.47) | 2.07 (1.45–15.55) | 0.686 |
| T max (h) | 1.00 (0.50–1.00) | 1.00 (0.50–2.00) | 0.752 |
| t 1/2 (h) | 0.52 (0.32–0.87) | 0.53 (0.37–0.66) | 0.976 |
| H4 | n = 23 | n = 6 | |
| AUC0–t (ng·h/mL) | 7.59 (4.73–18.83) | 6.52 (2.55–10.01) | 0.484 |
| C max (ng/mL) | 5.15 (3.10–10.07) | 4.62 (2.15–10.18) | 0.979 |
| T max (h) | 1.00 (0.50–1.00) | 1.00 (1.00–2.00) | 0.286 |
| t 1/2 (h) | 0.65 (0.39–0.99) | 0.42 (0.32–1.18) | 0.324 |
Data are presented as medians with interquartile range
AUC 0–t area under time–concentration curve, C max maximum concentration, T max time to reach maximum concentration, k elimination constant, t 1/2 elimination half-life