Table 6.

Statistical comparison of relative virulence for mice of Burkholderia strains and their in vivo isolates

Strain	Day 21a			Day 60a
	LD50	95 % credible interval		LD50	95 % credible interval
		Lower	Upper		Lower	Upper
Bp MSHR668	3.9 × 102	1.7 × 102	8.6 × 102	0.3	0	1.6 × 101
Bp 41-1	4.7 × 102	1.2 × 102	2.2 × 103	5.1	0.1	3.8 × 101
Bp 60-2	8.4 b	0.7	4.3 × 101	3.4	0.5	1.2 × 101
Bp K96243	2.3 × 104	1.2 × 104	4.7 × 104	1.9 × 103	4.7 × 102	6.1 × 103
Bp 49-4	4.3 × 104	2.3 × 104	7.7 × 104	1.9 × 10 2c	0.4	2.2 × 103
Bp 1106a	3.3 × 104	1.7 × 104	6.4 × 104	1.2 × 104	3.3 × 103	4.0 × 104
Bp 62-3	4.7 × 104	1.9 × 104	1.2 × 105	1.2 × 104	7.0 × 103	2.0 × 104
Bm FMH	3.3 × 107	1.4 × 107	7.6 × 107	1.1 × 107	2.1 × 106	7.2 × 107
Bm 60-5	2.1 × 107	1.2 × 107	3.7 × 107	2.9 × 10 6d	7.7 × 105	1.2 × 107

^aBALB/c mice were challenged by the IP route with a strain of Bp or Bm, or a spleen isolate of the strain, and the mice were monitored for morbidity and mortality for 60 days. The 21- and 60-day survival data were analyzed for each strain, and the data were evaluated statistically to compare parent strain and spleen derivative relative virulence potencies and LD₅₀ values (no. CFU) by using Bayesian probit analysis, as described in the methods. The bolded LD₅₀ values are those which were significantly different from the parent strain LD₅₀ value

^bThe day 21 LD₅₀ value of Bp 60-2 was less than that of parent strain MSHR668 (probability ≥95 %) and the isolate exhibited greater potency at all lethal doses up to 90 % (probability of mortality ≤0.9)

^cThe day 21 LD₅₀ values of K96243 and its isolate Bp 49-4 were not significantly different. The day 60 LD₅₀ of the isolate was about tenfold less than that of the parent, although not significantly different

^dAlthough the day 60 LD₅₀ for isolate Bm 60-5 was almost fourfold less than that of the parent strain, the values were not significantly different