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. 2017 Feb 14;8:97. doi: 10.3389/fimmu.2017.00097

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Copyright © 2017 Menezes, Leal, Dierckx, Khouri, Decanine, Silva-Santos, Schnitman, Kruschewsky, López, Alvarez, Talledo, Gotuzzo, Nixon, Vercauteren, Brassat, Liblau, Vandamme, Galvão-Castro and Van Weyenbergh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significant linear trend in Fas⁺ lymphocyte levels in PBMC of HC, AC, and HAM/TSP patients upon in vitro culture, and negative correlation with age of onset of HAM/TSP. (A) Fas levels were quantified by flow cytometry after 48 h of in vitro culture. Fas⁺ lymphocytes (%) gradually increase (HC: n = 12; AC: n = 4; HAM: n = 12) upon infection (AC) and further upon disease progression to HAM/TSP (ANOVA, p = 0.0005; posttest for linear trend, p < 0.0001). (B) Lymphocyte Fas levels (after 48 h of in vitro culture) quantified by flow cytometry (MFI) correlate negatively to age of onset in HAM/TSP patients (*p = 0.019, Pearson’s r = −0.69, n = 11).