Figure 6.

Fas surface expression correlates positively with in vitro and ex vivo lymphoproliferation in HAM/TSP patients. (A) In vitro Fas expression as measured by flow cytometry (MFI) correlates positively to lymphoproliferation quantified by [3H]-thymidine incorporation (*p = 0.018, Pearson’s r = 0.62, n = 14). (B) Ex vivo Fas surface expression measured by flow cytometry (% and MFI) is significantly higher in proliferating (tetraploid, 4n) cells vs. diploid (2n) cells in HAM/TSP patients (paired t-test, **p = 0.0082 and **p = 0.0023, respectively, n = 5).