Table 2.
Effect of age at leprosy diagnosis on association of rs6478108 with T1R.
| rs6478108-G allele |
|||
|---|---|---|---|
| Age at leprosy diagnosis | Samples | OR (95% CI) | p Value |
| <30 | Vietnam I | 2.34 (1.59–3.45) | 1.50E−05 |
| Vietnam II | 1.37 (1.06–1.75) | 0.02 | |
| Brazil I | 2.08 (0.96–4.50) | 0.06 | |
| Brazil II | 4.97 (1.88–13.2) | 0.001 | |
| Combined | 1.95 (1.54–2.46) | 2.50E−08 | |
| I2 (p value) | 55.3 | 0.06 | |
| 30–60 | Vietnam I | 0.40 (0.13–1.28) | 0.12 |
| Vietnam II | 1.35 (0.94–1.94) | 0.1 | |
| Brazil I | 0.69 (0.36–1.33) | 0.27 | |
| Brazil II | 1.85 (0.73–4.66) | 0.19 | |
| Combined | 1.04 (0.81–1.34) | 0.75 | |
| I2 (p value) | 53.6 | 0.07 | |
| >60 | Vietnam I | n.a. | n.a. |
| Vietnam II | n.a. | n.a. | |
| Brazil I | 0.76 (0.29–2.05) | 0.59 | |
| Brazil II | 1.85 (0.75–4.57) | 0.18 | |
| Combined | 1.21 (0.74–2.00) | 0.44 | |
| I2 (p value) | 0 | 0.43 | |
| All ages | Vietnam I | 2.13 (1.45–3.13) | 2.10E−04 |
| Vietnam II | 1.36 (1.09–1.70) | 0.007 | |
| Brazil I | 0.93 (054–1.57) | 0.77 | |
| Brazil II | 2.48 (1.14–5.37) | 0.02 | |
| Combined | 1.46 (1.23–1.73) | 1.50E−05 | |
| I2 (p value) | 54.9 | 0.06 | |
OR, odds ratio; CI, confidence interval; n.a., not applicable; T1R, type-1 reaction.