Table 4.

Gene expression findings in postmortem suicide brains.

System	Findings	Brain region	Gene	References
HPA Axis	Downregulation	PFC	CRHR1	Merali et al., 2004
	Upregulation	PFC, ACC	CRH	Zhao et al., 2015
	Downregulation	PFC, amygdala	GR-alpha	Pandey et al., 2013; Pérez-Ortiz et al., 2013
	Downregulation	amygdala	FKBP5	Pérez-Ortiz et al., 2013
	Upregulation	Pituitary	POMC	López et al., 1992
Serotonergic	Upregulation	Cortex, hippocampus	5HT2A	Stanley and Mann, 1983; Turecki et al., 1999; Pandey et al., 2002; Escribá et al., 2004
	Upregulation of edited isoform of pre-mRNA	PFC	5HT2C	Niswender et al., 2001; Lyddon et al., 2013; Di Narzo et al., 2014
Noradrenergic	Upregulation	Locus coeruleus	TH	Pandey and Dwivedi, 2007
	Upregulation	PFC	α2 adrenergic receptor	Pandey and Dwivedi, 2007
	Inconclusive data	PFC	β2 adrenergic receptor	Pandey and Dwivedi, 2007
	Upregulation	Cortex	COMT	Du et al., 2014
Neurotrophins	Downregulation	PFC, hippocampus	BDNF	Dwivedi et al., 2003a; Banerjee et al., 2013; Du et al., 2014
	Downregulation	Hippocampus	NGF	Banerjee et al., 2013
	Downregulation	PFC, hippocampus	TRKB	Dwivedi et al., 2003a; Ernst et al., 2009; Banerjee et al., 2013
	Downregulation	hippocampus	TRKA	Banerjee et al., 2013
	Downregulation	PFC, hippocampus	PI-3	Dwivedi et al., 2008
	Downregulation	PFC, hippocampus	CREB	Dwivedi et al., 2003b; Pandey et al., 2007

PFC, prefrontal cortex; ACC, anterior cingulate cortex.