Table 2.
Differences in study variables for the different variants of FSH R polymorphisms c.2039 A>G and c.-29 G>A
| c.2039 A>G | c.-29 G>A | |||||||
|---|---|---|---|---|---|---|---|---|
| A/A | A/G | G/G | p | G/G | G/A | A/A | p | |
| Age1 | 32.0 (21–40) | 33.0 (21–42) | 32.5 (21–40) | 0.46 | 33.0 (21–42) | 33.0 (22–41) | 30.0 (26–35) | 0.30 |
| BMI (kg/m2)1 | 22.7 (17.8–29.1) | 22.7 (17.8–29.8) | 22.0 (18.9–29.9) | 0.38 | 22.0 (17.6–29.8) | 22.5 (17.8–29.0) | 23.0 (21.0–29.0) | 0.60 |
| Basal FSH (IU/L)1 | 6.56 (3.7–13.8) | 6.29 (3.3–13.1) | 7.37 (4.8–13.1) | 0.06 | 6.5 (3.3–13.1) | 7.1 (4.0–13.1) | 7.2 (5.8–8.0) | 0.26 |
| Basal 17β E2 (pg/mL)1 | 59.4a (10–232) | 40.0b (9–104) | 50.0ab (18–99) | 0.02 | 44.0 (9–232) | 49.0 (13–104) | 67.0 (48–99) | 0.06 |
| AMH (ng/mL)1 | 1.4 (0.2–3.5) | 1.7 (0.3–3.5) | 2.2 (0.1–3.1) | 0.49 | 1.8 (0.4–3.2) | 1.6 (0.1–3.5) | 0.2 (0.2–0.3) | 0.06 |
| Antral follicle count1 | 9.0 (3–18) | 10.0 (3–46) | 8.0 (8–25) | 0.44 | 10.0b (1–46) | 8.0ab (2–25) | 6.0a (4–14) | 0.04 |
| Starting dose of rhFSH (IU)1 | 150 (75–300) | 150 (75–450) | 150 (75–450) | 0.92 | 150.0 (75–450) | 150.0 (75–450) | 150.0 (75–150) | 0.89 |
| Days of rhFSH treatment1 | 12 (7–17) | 11.5 (6–19) | 12 (7–15) | 0.80 | 12 (7–17) | 12 (6–19) | 15 (10–17) | 0.13 |
| Total dose of rhFSH (IU)1 | 1687.5 (900–4050) | 1875.0 (863–6300) | 1954.0 (675–4125) | 0.60 | 1800.0 (675–4125) | 1800.0 (850–6300) | 3000.0 (1800–3825) | 0.17 |
| 17β E2 on the hCG day (pg/mL)1 | 1274.0 (304–2352) | 1390.0 (210–3965) | 1479.0 (329–3507) | 0.68 | 1384.0 (304–3965) | 1314.0 (210–2600) | 1388.0 (631–1954) | 0.91 |
| Number of follicles >16 mm on the hCG day1 | 6.0 (2–13) | 6.5 (1–13) | 7.0 (3–10) | 0.39 | 6.0 (2–11) | 7.0 (1–13) | 6.0 (5–8) | 0.65 |
| FORT2 | 69% | 63% | 76% | 0.09 | 63% | 73% | 79% | 0.07 |
| Retrieved oocytes3 | 7.17 (±2.4) | 8.12 (±2.2) | 6.74 (±2.4) | 0.54 | 8.2 (±4.7) | 6.7 (±3.5) | 6.2 (±4.1) | 0.84 |
| Clinical pregnancy per ET4 | 7/27 (26%) | 20/68 (30%) | 8/28 (29%) | 0.94 | 21/76 (28%) | 12/43 (28%) | 2/4 (50%) | 0.64 |
Differences among figures with common superscript letters are not significant
1Values are expressed in median and range in brackets. 2FORT is expressed in percentage. 3Retrieved oocytes are expressed in mean and standard deviation in brackets. 4Pregnancies per embryo transfer are expressed in number and percentage