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DNMT3A genotype and allele frequencies and their association with spontaneous abortion (SA)
| Genotypes | SA group (n = 152) |
Control group (n = 155) |
Odds ratio (95 % CI) |
P valuea | ||
|---|---|---|---|---|---|---|
| Number | (%) | Number | (%) | |||
| DNMT3A −448A > G | ||||||
| GG | 69 | (45.4) | 106 | (68.4) | 1.0 | |
| AG | 62 | (40.8) | 47 | (30.3) | 2.027 (1.247–3.293) | 0.004 |
| AA | 21 | (13.8) | 2 | (1.3) | 16.130 (3.665–70.984) | 0.000 |
| A allele | 34.2 % | 16.5 % | ||||
GG wild-type homozygotes, AG heterozygotes, AA variant homozygotes
aTwo-sided χ 2 test
