Table 3.
Stratification analysis of DNMT3A genotype frequencies, ORs, and 95 % CIs
| Genotype | Spontaneous abortions (%) | Controls (%) | OR (95 % CI) | P value |
|---|---|---|---|---|
| Gestation | ||||
| <12 weeks | ||||
| GG | 58 (38.2) | 98 (63.2) | 1.0 | |
| AG | 57 (37.5) | 42 (27.1) | 2.293 (1.371–3.834) | 0.001 |
| AA | 20 (13.2) | 2 (1.3) | 16.897 (3.810–74.925) | 0.000 |
| ≥12 weeks | ||||
| GG | 11 (7.2) | 8 (5.2) | 1.0 | |
| AG | 5 (3.3) | 5 (3.2) | 0.727 (0.156–3.386) | 0.684 |
| AA | 1 (0.7) | 0 (0) | – | 0.240 |
| Age | ||||
| <35 years | ||||
| GG | 53 (34.9) | 90 (58.1) | 1.0 | |
| AG | 47 (30.9) | 42 (27.1) | 1.900 (1.111–3.251) | 0.019 |
| AA | 17 (11.2) | 1 (0.6) | 28.868 (3.734–223.156) | 0.000 |
| ≥35 years | ||||
| GG | 16 (10.5) | 16 (10.3) | 1.0 | |
| AG | 15 (9.9) | 5 (3.2) | 3.000 (0.880–10.229) | 0.074 |
| AA | 4 (2.6) | 1 (0.6) | 4.000 (0.402–39.827) | 0.211 |