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. 2016 Dec 2;31(2):241–257. doi: 10.1038/eye.2016.275

Table 6. Features predictive of poor prognosis for posterior uveal melanoma.

Clinical features
 Older age at presentation
 Male gender
 Larger tumor basal diameter
 Increased tumor thickness
 Ciliary body tumor location
 Diffuse tumor configuration
 Association with ocular/oculodermal melanocytosis
 Extraocular tumor extension at presentation
 Advanced AJCC category and staging
 
Histopathologic features
 Epithelioid cytology on histopathology
 High mitotic activity/PC-10/Ki-67
 High values of mean diameter of 10 largest nucleoli
 High microvascular density
 Microvascular loops and patterns
 Tumor-infiltrating lymphocytes
 Tumor-infiltrating macrophages
 High expression of insulin-like growth factor 1 receptor
 High expression of HLA class I and II
 
Cytogenetic features
 Chromosome 3-loss (monosomy 3)
 Chromosome 8q-gain or 8p-loss
 Chromosome 1p-loss
 Chromosome 6q-loss
 
Transcriptomic feature
 Gene expression profile class 2