Clinical features |
Older age at presentation |
Male gender |
Larger tumor basal diameter |
Increased tumor thickness |
Ciliary body tumor location |
Diffuse tumor configuration |
Association with ocular/oculodermal melanocytosis |
Extraocular tumor extension at presentation |
Advanced AJCC category and staging |
|
Histopathologic features |
Epithelioid cytology on histopathology |
High mitotic activity/PC-10/Ki-67 |
High values of mean diameter of 10 largest nucleoli |
High microvascular density |
Microvascular loops and patterns |
Tumor-infiltrating lymphocytes |
Tumor-infiltrating macrophages |
High expression of insulin-like growth factor 1 receptor |
High expression of HLA class I and II |
|
Cytogenetic features |
Chromosome 3-loss (monosomy 3) |
Chromosome 8q-gain or 8p-loss |
Chromosome 1p-loss |
Chromosome 6q-loss |
|
Transcriptomic feature |
Gene expression profile class 2 |