. 2016 Oct 16;83(3):554–561. doi: 10.1111/bcp.13132

Table 2.

Neratinib pharmacokinetic parameters in plasma

Parameter	Neratinib (Period 1) (n = 15)	Neratinib + Lansoprazole (Period 2) (n = 15) ^d
C _max ( ng ml ⁻¹ ) ^a	84.5 (49%)	24.5 (48%)
T _max (h) ^b	5.75 (3.51, 6.50)	7.25 (5.00, 24.0)
AUC _0–t ( ng ml ⁻¹ h) ^a	1478 (43%)	426 (57%)
AUC _0–inf ( ng ml ⁻¹ h) ^a	1557 (41%)	538 (42%)
t _½ (h) ^c	13.8 ± 2.2	13.9 ± 2.3

AUC_0–inf, area under the plasma concentration–time curve from time 0 extrapolated to infinity; AUC_0–t, area under the plasma concentration–time curve, from time 0 to the last measurable nonzero concentration; C_max, peak plasma concentration; t_½, apparent first‐order terminal elimination half‐life; T_max, time to reach C_max

^{^a}

Geometric mean (geometric coefficient of variation)

^{^b}

Median (range)

^{^c}

Arithmetic mean ± standard deviation

^{^d}

n = 14 for AUC_0‐inf