Figure 3.

Mean prostate specific antigen (PSA) in exposed and control patients (A) for 2 years before and after their index dates and (B) for 2 years before and after discontinuation of spironolactone. PSA levels were similar in the exposed and control cohorts before the index date, but lower in the spironolactone cohort after the index date suggesting that spironolactone exposure is associated with lower PSA levels. Within 2 months of spironolactone discontinuation, PSA levels in the exposed cohort returned to levels not significantly different to those in control patients