Table 3.

Distribution of covariates in the control and exposed cohorts

	Control cohort		Exposed cohort
	n	%	n	%
Total	147 953	100.0	74 272	100.0
Sex
Male	67 441	45.6	33 865	45.6
Female	80 512	54.4	40 407	54.4
Age group
Under 40 years	9796	6.6	4635	6.2
40–49 years	8994	6.1	4602	6.2
50–59 years	16 574	11.2	8065	10.9
60–69 years	28 142	19.0	13 887	18.7
70–79 years	39 622	26.8	20 219	27.2
80–89 years	36 087	24.4	18 403	24.8
≥90 years	8738	5.9	4461	6.0
Year of index date
1987–1995	13 760	9.3	6917	9.3
1996–2000	19 999	13.5	10 037	13.5
2001–2005	50 809	34.3	25 508	34.3
2006–2010	46 108	31.2	23 143	31.2
2011–2013	17 277	11.7	8667	11.7
History of drug use
Oral contraceptives a	4692	3.2	2368	3.2
Hormone replacement therapy a	12 942	8.7	6332	8.5
Metformin	15 068	10.2	8932	12.0
Aspirin	65 507	44.3	36 310	48.9
Digoxin	14 381	9.7	16 781	22.6
ACE inhibitors	69 678	47.1	41 083	55.3
Family history of cancer	2629	1.8	1269	1.7
Medical history
Hypertension	75 674	51.1	36 634	49.3
Heart failure	15 546	10.5	25 552	34.4
Liver disease	3412	2.3	4773	6.4
Diabetes mellitus	24 957	16.9	14 457	19.5
Abdominal pain	26 881	18.2	14 233	19.2
BMI 25–30 kg m −2	82 386	55.7	42 121	56.7
BMI > 30 kg m −2	44 071	29.8	23 452	31.6
> 21 units alcohol/week	12 086	8.2	6323	8.5
Never smoked	61 781	41.8	31 012	41.8
> 20 cigarettes/day	7357	5.0	3798	5.1
1	16 685	11.3	7998	10.8
2	18 496	12.5	9199	12.4
3	18 565	12.5	9342	12.6
4	17 705	12.0	8909	12.0
5	11 835	8.0	6119	8.2
Not available	64 667	43.7	32 705	44.0

^aNumber and percentage of women

ACE = angiotensin‐converting enzyme; BMI = body mass index