Table 3.
Association of TCL1A, ABCB1 and CYP19A1 polymorphisms with the onset of arthralgia in postmenopausal, hormone‐receptor positive breast cancer patients
| Arthralgia | ||||
|---|---|---|---|---|
| TCL1A | No (%) | Yes (%) | OR (95% CI) | P‐value |
| rs7158782–rs2369049 a | ||||
| A/A | 72.0 | 75.6 | Ref. | |
| A/G‐G/G | 28.0 | 24.4 | 0.88 (0.33–2.36) | 0.8 |
| rs7159713 A/G | ||||
| A/A | 72.0 | 74.4 | Ref. | |
| A/G‐G/G | 28.0 | 25.6 | 0.95 (0.36–2.54) | 0.93 |
| rs11849538 C/G | ||||
| C/C | 72.0 | 82.1 | Ref. | |
| C/G‐G/G | 28.0 | 17.9 | 0.61 (0.22–1.70) | 0.35 |
| Arthralgia | ||||
|---|---|---|---|---|
| ABCB1 | No (%) | Yes (%) | OR (95% CI) | P‐value |
| ABCB1 1236 | ||||
| C/C‐C/T | 65.6 | 84.1 | Ref. | |
| T/T | 34.4 | 44.1 | 0.40 (0.15–1.08) | 0.074 |
| ABCB1 2677 | ||||
| G/G‐G/T | 68.8 | 88.1 | Ref. | |
| T/T | 31.3 | 40.1 | 0.52 (0.19–1.41) | 0.2 |
| ABCB 3435 | ||||
| C/C‐C/T | 65.6 | 84.1 | Ref. | |
| T/T | 34.4 | 44.1 | 0.32 (0.11–0.89) | 0.029 |
| Arthralgia | ||||
|---|---|---|---|---|
| CYP19A1 | No (%) | Yes (%) | OR (95% CI) | P‐value |
| rs727479 A/C | ||||
| A/A‐A/C | 93.8 | 91.0 | Ref. | |
| C/C | 6.3 | 9.0 | 1.40 (0.27–7.38) | 0.68 |
| rs1008805 A/G | ||||
| A/A‐A/G | 59.4 | 85.9 | Ref. | |
| G/G | 40.6 | 14.1 | 0.24 (0.09–0.65) | 0.004 |
| rs749292 A/G | ||||
| G/G‐A/G | 90.6 | 83.3 | Ref. | |
| A/A | 9.4 | 16.7 | 1.80 (0.46–6.99) | 0.38 |
| rs730154 C/T | ||||
| C/C‐C/T | 96.9 | 98.7 | Ref. | |
| T/T | 3.1 | 1.3 | 0.45 (0.03–7.38) | 0.58 |
Ref., reference; OR, odds ratio; CI, confidence interval
a
These two single‐nucleotide polymorphisms were in complete linkage disequilibrium