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Oxidative metabolism of amodiaquine (AQ) and N‐desethylamodiaquine (DEAQ) by recombinant human P450 (supersomes). (A) Formation of DEAQ from AQ (A); (B) formation of AQ‐SG from AQ; (C) formation of DEAQ‐SG from DEAQ. AQ and DEAQ were incubated at two concentrations in presence of 100 nmol l–1 of each recombinant hCYPs. Control 1, empty baculosomes; Control 2, human CYP reductase; Control 3, baculosomes expressing only human CYP reductase
