Table 2.

Observation for toxicity symptoms as defined in the Common Toxicity Criteria developed by the Cancer Therapy Evaluation Program (National Cancer Institute, 1999, Common Toxicity Criteria Version 2.0, Cancer Therapy Evaluation Program).

	Observation	Control group		Test groups (500 mg/kg B. Wt., 1000 mg/kg B. Wt., 1500 mg/kg B. Wt., and 2000 mg/kg B. Wt.)
		Male	Female	Male	Female
1	Skin and fur	Normal	Normal	Normal	Normal
2	Eyes	Normal	Normal	Normal	Normal
3	Mucous membrane	Normal	Normal	Normal	Normal
4	Behavioural patterns	Normal	Normal	Normal	Normal
5	Salivation	Normal	Normal	Normal	Normal
6	Lethargy	Normal	Normal	Normal	Normal
7	Sleep	Normal	Normal	Normal	Normal
8	Diarrhea	Normal	Normal	Normal	Normal
9	Coma	NO	NO	NO	NO
10	Tremors	NO	NO	NO	NO
11	Vomiting and hematemesis (vomiting blood)	NO	NO	NO	NO
12	Hematochezia (bloody stools)	NO	NO	NO	NO
13	Loss of appetite	NO	NO	NO	NO
14	Dysphagia (inability to swallow)	NO	NO	NO	NO
15	Constipation	NO	NO	NO	NO

NO = not observed.