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. 2017 Feb 14;4(1):ENEURO.0373-16.2017. doi: 10.1523/ENEURO.0373-16.2017

Figure 2.

Figure 2.

Biphasic regulation of p38 MAPK by one 5-min pulse of 5-HT (50 μM). A, Representative confocal images of p-p38 MAPK immunofluorescence in Aplysia SNs at different times after onset of 5-HT. Scale bar, 20 μm. B, Summary data. The percent change was calculated as the change of p-p38 MAPK level after 5-HT compared with control level. 5-HT induced a delayed increase in p-p38 MAPK, following a transient decrease immediately after treatment. p-p38 MAPK returned to the control level at 60 min. C, Statistical analysis revealed significant differences between Veh and 5-HT treatment groups at 5 and 45 min. p-p38 MAPK levels were normalized to the mean of Veh controls. Significant differences between the groups are indicated by * for p < 0.05.