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Computational simulation of the ratio of pERK to p-p38 MAPK after two or five pulses of 5-HT. A, Dynamics of pERK and p-p38 MAPK levels, and the ratio of pERK to p-p38 MAPK, for 2 hours after two pulses with ISI of 45 min (A1) or 60 min (A2). B, Dynamics of the ratio of pERK to p-p38 MAPK for two hours after five pulses with ISIs of the standard protocol (B1) or enhanced protocol (B2) as compared with the peak ratio of pERK to p-p38 MAPK after one pulse (∼1.2, dashed line).
