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. 2017 Feb 14;7:41927. doi: 10.1038/srep41927

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Copyright © 2017, The Author(s)

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CL1-5 cells were transfected with pcDNA3.1-AhR for 24 h and autophagy-related proteins were then analysed by western blotting. (a) Western blotting showed that AhR overexpression decreased the levels of BNIP3 and LC3II/LC3I ratio. (b) BafA1 (5 nM) treatment of wild-type and AhR-overexpressing cells to compare autophagy flux. Quantification of the western blot data showing the fold-changes in BNIP3, p62, ATG12-5, LC3, and ATG7 expression. Full-length blots are presented in Supplementary Fig. S16. The data were analysed and expressed as the mean ± SD from three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 compared with the control group. ^###P < 0.001 indicate a statistical difference between wild-type and AhR overexpression cells in BafA1 treatment groups.