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. 2017 Feb 14;7:42041. doi: 10.1038/srep42041

Figure 5. Inhibition of microglial activation attenuates the NG2 glial cell ablation-induced hippocampal cell death.

Figure 5

(a) Timeline of the experimental design for the treatment with minocycline. (b) Immunohistochemical observations of Iba1 (upper panels) and NeuN (lower panels) in the hippocampal CA1 region of NG2-HSVtk transgenic rats treated with vehicle (Control), GCV for 2 days (GCV2d), or co-treatment with GCV and minocycline (45 mg/kg/day) for 2 days (GCV2d + minocycline). (c) The number of viable CA1 pyramidal neurons in NG2-HSVtk transgenic rats treated with vehicle (n = 3), GCV for 2 days (n = 6), or co-administration of GCV and minocycline (n = 3). p = 0.024, based on a the Student’s t-test analysis. Scale bars represent 100 μm (b).