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. 2017 Feb 14;7:42041. doi: 10.1038/srep42041

Figure 7. Ablation of NG2 glial cells induces the reduction of HGF in the hippocampus.

Figure 7

(a) Confocal images of immunoreactivity for hepatocyte growth factor (HGF) (green), NG2 (magenta), and Olig2 (cyan) in NG2-HSVtk transgenic rats. (b) Relative expression levels of HGF mRNA in the hippocampus of NG2-HSVtk transgenic rats treated with vehicle (Control, the value as 1.0) or GCV for 1, 2, 3 days (GCV1d, GCV2d, GCV3d). (c) Relative protein abundance of HGF evaluated based on a densitometry analysis using ImageJ in the hippocampus of NG2-HSVtk transgenic rats treated with vehicle (Control, the value as 1.0) or GCV for 1, 2, or 3 days. The amount of total protein was used as a loading control. Mean ± SD, n = 3 animals (Control, GCV3d) or 4 animals (GCV1d, GCV2d); *p < 0.05 or ***p < 0.005, based on a one-way ANOVA followed by Tukey-Kramer test (b,c). Scale bar represents 50 μm (a).