Figure 1. Expression profiles and enrichment Analysis of mRNAs/lncRNAs regulated by let-7e.

(a) The percentage of down-regulated mRNAs (lncRNAs) in all regulated mRNAs (lncRNAs) in HUVECs treated by let-7e mimic or inhibitor. ^★p < 0.05 vs. the percentage of down-regulated lncRNAs in HUVECs treated with let-7e mimic. *p < 0.05 vs. the percentage of down-regulated lncRNAs in HUVECs treated by let-7e inhibitor. (b) 385 mRNAs potentially targeted by let-7e and (c) 102 lncRNAs potentially binding to let-7e in HUVECs were hierarchically clustered. The effects of let-7e mimic and inhibitor (50 nM each) were obvious. The effects of let-7e mimic were predominantly inhibitory, while the effects of let-7e inhibitor were permissive. (d) The gene set enrichment analysis of the above-mentioned 487 transcripts was performed as described in the Methods section. Multiple testing was adjusted using the Benjamini–Hochberg correction. AdjP: adjusted P-value. The dotted line showed −log₁₀ (0.05).