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. 2017 Feb 14;7:42476. doi: 10.1038/srep42476

Figure 4. Levels of gene expression and H3K27me3 enrichment in the Slc6a3 gene, and dopamine concentrations in the midbrain.

Figure 4

(a) The expression levels of Slc6a3 measured by microarray. The average of wild-type (WT) samples was set as 1. *P < 0.05 (WT vs. knockout (KO) mice, t test). (b) The expression levels of Slc6a3 measured by RT-qPCR analysis. The mean level of WT was set as 1. *P < 0.05 (WT vs. KO mice, t test). Data are presented as the mean ± S.D. (c) ChIP analysis of enrichment of H3K27me3. There was a significant difference in the body of Slc6a3, but not in the promoter region. *P < 0.05 (WT vs. KO mice, t test). See Materials and Methods for the calculation method of the relative occupancy. Data are presented as the mean ± S.D. (d) Dopamine concentrations in the midbrain. There were no genotype-related differences. All data were obtained from mice of line A. The dashed lines represent the average values of each group.