Figure 4. Qualitative neural crest defects in Xenopus with cyclopamine treatment.

Stage 46 uninjected control tadpole compared to cyclopamine treated tadpoles and demonstrated the teratogenic effects. (a–c) Left column shows the control and the right column shows the cyclopamine treated tadpole. In cyclopamine treated tadpoles both jaws were short and thick. Meckel and ceratohyal cartilage were smaller and gill cartilages were nearly lost. (Scale Bar on x and y axis: 0–2 mm).