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. 2017 Feb 14;7:42477. doi: 10.1038/srep42477

Figure 4. Pemafibrate modulated lipid turnover and upregulated expression of UCP3 in the liver.

Figure 4

(A) mRNA expressions involved in lipid metabolism (fatty acid transport protein 4 (FATP4), sterol regulatory element-binding protein 1c (SREBP1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1), peroxisome proliferator activated receptor α (PPARα), acyl-CoA oxidase (ACOX), carnitine palmitoyltransferase 1 A (CPT1A), and microsomal triglyceride transfer protein (MTTP)) and expression of uncoupling protein 3 (UCP3) in BD, CTRL, PEMA-L, PEMA-H, and FENO mice (n = 5–10). (B) SREBP1, ACOX1, and UCP3 protein levels in BD, CTRL, PEMA-L, PEMA-H, and FENO mice (n = 5). Results are the mean ± SE. Significance was determined using Student’s t-test (†p < 0.05 versus CTRL mice) or Dunnett’s test (*p < 0.05 versus CTRL mice).