Table 1.
Clinical characteristics of the patients: data are presented as mean (S.D.) or median (IQR) where appropriate
| Survivors n = 225 |
Non-survivors n = 101 |
Total n = 326 |
p | |
|---|---|---|---|---|
| Patients from Valladolid (n, %) | 102 (45.3%) | 35 (34.7%) | 137 | 0.071 |
| Patients from Dijon (n, %) | 123 (54.7%) | 66 (65.3%) | 189 | |
| Male (n, %) | 133 (59.1%) | 68 (67.3%) | 201 (61.4%) | 0.098 |
| Age (years) (mean, SD) | 63 (14) | 69 (12) | 65.4 (14) | <0.001 |
| SOFA (mean, SD) | 8 (3.4) | 11 (3.5) | 9 (3.7) | <0.001 |
| Septic shock (n, %) | 152 (67.5%) | 87 (86.1%) | 239 (73.3%) | 0.020 |
| Mechanical ventilation (n, %) | 150 (66.7%) | 89 (88.1%) | 239 (73.3%) | <0.001 |
| RRT (n, %) | 40 (17.7%) | 45 (44.6%) | 85 (26.2%) | <0.001 |
| ICU stay (days) (mean, SD) | 12.9 (18) | 7.7 (6.7) | 11.2 (15.6) | 0.012 |
| Neoplasia (n, %) | 47 (21%) | 35 (34.7%) | 82 (25.2%) | 0.007 |
| Diabetes (n, %) | 58 (25.8%) | 29 (28.7%) | 87 (26.7%) | 0.330 |
| COPD (n, %) | 33 (14.7%) | 16 (15.8%) | 49 (15%) | 0.450 |
| Cardiovascular disease (n, %) | 56 (25%) | 41 (40.6%) | 97 (29.8%) | 0.030 |
| Chronic renal failure (n, %) | 16 (7.1%) | 16 (15.8%) | 32 (9.8%) | 0.014 |
| Immunosuppression (n, %) | 21 (9.3%) | 25 (24.8%) | 46 (14.1%) | <0.001 |
| Respiratory infection (n, %) | 98 (43.6%) | 58 (57.4%) | 156 (48%) | 0.014 |
| Urologic infection (n, %) | 75 (33.3%) | 36 (35.6%) | 111 (34%) | 0.380 |
| Abdominal infection (n, %) | 25 (11.1%) | 10 (9.9%) | 35 (10.7%) | 0.450 |
| Other infection (n, %) | 32 (14%) | 11 (10.9%) | 43 (13%) | 0.40 |
| Primary or secondary bacteremia (n, %) | 69 (30.7%) | 38 (37.6%) | 107 (32.8%) | 0.130 |
| Gram − bacteria (n, %) | 62 (27.6%) | 28 (27.7%) | 90 (27.6%) | 0.975 |
| Gram + bacteria (n, %) | 47 (20.9%) | 22 (21.8%) | 69 (21.2%) | 0.855 |
| Fungi (n, %) | 3 (1.3%) | 5 (5%) | 8 (2.5%) | 0.050 |
| Virus (n, %) | 15 (6.7%) | 5 (5%) | 20 (6.1%) | 0.550 |
| MR-proADM (nmol/L) (median, IQR) | 2.68 (3.56) | 7.44 (6.84) | 3.62 (5.6) | <0.001 |
| Lactate (mmol/L) (median, IQR) | 2.00 (1.54) | 3.60 (5.53) | 2.12 (2.28) | <0.001 |
| CRP (mg/dl) (median, IQR) | 147.8 (193.6) | 163.0 (181.9) | 155.0 (189) | 0.200 |
| PCT (ng/ml) (median, IQR) | 2.9 (17.5) | 5.8 (36.7) | 3.54 (27.5) | 0.001 |
Values expressed in percentages (%) indicate the proportion of survivors and non-survivors at 28 days for specific variables