Fig. S1.

E6/E7 repression is not linked to HIF-1α or HIF-2α expression. (Upper, Left) Immunoblot analyses investigating the effects of the HIF agonists CoCl₂, mimosine, or DMOG on E7 levels in normoxic HeLa cells. (Upper, Center and Right) Analyses of the effects of shRNAs blocking HIF-1α (shHIF-1α-1, shHIF-1α-2) or HIF-2α (shHIF-2α-1, shHIF-2α-2) expression, respectively, on hypoxia-linked E7 repression. (Lower) Analyses of the effects of pooled shRNAs blocking HIF-1α (shHIF-1α) or HIF-2α (shHIF-2α), applied either alone or in combination, on hypoxia-linked E6 and E7 repression. β-actin served as a loading control.