Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The short-circuit mechanism of autoinhibition used by IpaH9.8 is not used by Smurf2 and produces a dominant-negative effect on other E3s. (A) Kinetics of Ub charging and discharging for full-length Smurf2 (FL) or its isolated HECT domain. (B) Dominant-negative effect of autoinhibited IpaH9.8 on the Ub ligase activity of constitutively active Smurf2 HECT domain in vitro.
