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Cardiac function in WT and HO-2−/− mice. (A) Representative transthoracic echocardiographic M-mode images of the left ventricle in 6-mo-old WT and HO-2−/− mice. Arrows indicate left ventricular internal dimensions in diastole (LVIDd) and systole (LVIDs). (B–D) Fractional shortening (FS) (B), LVIDd (C), and LV wall thickness (D) are shown as mean ± SEM from WT and HO-2−/− mice (n = 6 each).
