Table 2.
Chromosomal translocations identified by SKY analysis in grade II meningioma fragments 2, 3 and 4
| Metaphase state | ||||
|---|---|---|---|---|
| Normal | Abnormal | Shattered | ||
| Sample | Non-recurrent | Recurrent | ||
| Grade II-2 | 40% | 40% | 0% | 20% |
| 46, XX, t(10;18) | ||||
| 46, XX, t(1;8) | ||||
| 46, XX, t(5;14) | ||||
| Grade II-3 | 20% | 30% | 50% | 0% |
| 46, XX, t(11;8) | 46, XX, t(8;8), t(11;12) | |||
| 46, XX, t(1;2), t(2;4), t(7;8), t(9;21) | ||||
| 46, XX, t(1;3;22), t(11;21), t(2;18) | ||||
| Grade II-4 | 20% | 0% | 80% | 0% |
| 46, XX, t(3;13;14), t(17;21) | ||||
| 46, XX, t(3;13;14), t(17;21), inv(12) | ||||
Percent of normal metaphases and metaphases containing chromosomal translocations (abnormal) is shown in the top row for each meningioma grade II primary tissue culture analyzed (Grade II-2, II-3 and II-4, note that culture from fragment II-1 could not be established). Abnormal metaphases were further divided into recurrent or non-recurrent. Fragment 2 of the tumor (Grade II-2) also contained 20% of cells with highly fragmented, shattered chromosomes