Table 1.
Dataset Name | Tissue/cell-types | Use in Reference DNAm Database | Testing/Evaluation | Reference |
---|---|---|---|---|
Reinius et al. | WB, PBMC, NK, B, CD4T, CD8T, Monoc, Neutro, Eosino. (n = 6 of each) | NK, B, CD4T, CD8T, Monoc., Neutro., Eosino. | WB & PBMC | [24] |
Liu et al. | WB (n = 335 controls, n = 354 rheumathoid arthritis cases) | No | Average Flow Cytometry estimates for cases and controls | [2] |
Koestler et al. | WB (n = 18) | No | 12 Reconstructed WB mixtures + 6 WB samples with Flow Cytometry estimates | [20] |
Zilbauer et al. | PBMC, CD4T, CD8T, NK, B, Monoc, Neutro. (n = 6 of each) | No | In-silico mixtures of purified blood cell subtypes | [27] |
ENCODE | Various | HMEC, HRCE, IMR90, Liver | No | [22] |
Slieker et al. | Various | Pancreas | Liver | [26] |
SCM2 | Various | No | HRCE, Pancreas, IMR90 | [29] |
Lowe et al. | Various | No | HMEC | [28, 35] |
Teschendorff et al. | WB (n = 152) | No | Smoking associated DMCs | [31] |
Abbreviations: DNAm = DNA methylation, WB = whole blood, PBMC = peripheral blood mononuclear cells, HMEC = human mammary epithelial cells, HRCE = human renal cortical epithelia, IMR90 (fetal lung fibroblast), SCM2 = Stem-Cell-Matrix Compendium-2, DMCs = differentially methylated CpGs, NK = natural killer cells, B = B-cell, Monoc = Monocytes, Neutro. = Neutrophils, Eosino = Eosinophils, CD4T = CD4+ T-cells, CD8T = CD8+ T-cells