Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A flow chart giving an overview of the order of steps performed in the combined algorithm. This chart only represents the high-level actions of the algorithm with many of the blocks representing subroutines that are somewhat more nuanced in practice. A detailed account of all steps can be found in the Additional file 1
