Fig. 1.

Schematic representation of XPO1-mediated nuclear export. RanGDP (D) is converted to RanGTP (T) through the action of RCC1 (the Ran guanine exchange factor). The export complex composed of RanGTP, cargo (C), and XPO1 (X) proteins shuttles through the nuclear pore complex (NPC) into the cytoplasm where RanGTP is dephosphorylated by the action of RanGAP, the Ran GTPase-activating protein. Cargo/XPO1 complexes are dissociated, and XPO1 shuttles back to the nucleus for further rounds of nuclear export