Fig. 2.

Buformin diet inhibits syngeneic tumor growth in MMTV-erbB-2 mice. 8-week-old MMTV-erbB-2 mice were inoculated with 78617 cells and tumors began to appear by Day 6 after the initial inoculation. At Day 6, mice (N = 7) were administered a buformin diet for 12 days with tumor palpitation every 2 days. The tumor volumes during the monitoring from Day 6 – 18 (a) and final tumor weights (b) were recorded. Representative images of tumors from the control and buformin-fed mice are shown in c. Values are graphed as the mean ± S.E. (**p < 0.01)