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. 2017 Feb 14;16:37. doi: 10.1186/s12943-017-0609-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Full-length ALK expression in UCSs. a Staining by HE and IHC for ALK. Note the strong cytoplasmic ALK immunoreactivity in both carcinomatous (indicated by a and arrow) and sarcomatous components (indicated by b and asterisk) (indicated by closed boxes and magnified in the insets) in UCS51 (mixed type), UCS47 (epithelial type), and UCS33 cases (stromal type). Original magnification, ×100 and × 400 (inset). b Staining by HE and ISH for ALK mRNA. Note the mRNA signals in carcinomatous (a) and sarcomatous cells (b) (indicated by closed boxes and magnified in the insets) in UCS35 (mixed type), UCS29 (epithelial type), and UCS37 cases (stromal type). Original magnification, ×100 and × 400 (inset). c ALK IHC score in ALK mRNA-positive (P) and −negative (N) UCS cases. The data shown are means ± SDs. d FISH analysis of UCS33 and UCS47 cases. The interphase nuclei of both cases indicate absence of ALK rearrangement, in which the red and green signals remain fused (arrows)