Table 5.
Analysis of metabolic variables with the components of metabolic syndrome at first assessment
| Outcome variables | Fat percentage tertile (values)a | HOMA-IR tertile a | Adiponectin tertilea | Leptin tertilea | Leptin adiponectin ratio tertilea | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2 (24.2–35.0) | 3 (35.1–46.7) | 2 (3.6–5.5) | 3 (5.6–13.9) | 2 (15.3–25.4) | 3 (25.5–44.3) | 2 (4.1–13.4) | 3 (13.5–30.8) | 2 (0.3–0.7) | 3 (0.8–2.9) | |
| MS | ||||||||||
| Waist circumference (cm) | ||||||||||
| Coeficient | 9.5 | 17.7 | 6.2 | 13.8 | −1.9 | −6.2 | 7.6 | 15.7 | 10.0 | 14.6 |
| 95% CI | 3.4; 16.6 | 11.6; 23.7 | −0.6; 13.1 | 6.9; 20.7 | −10.1; 6.3 | −14.4; 1.9 | 0.6; 14.6 | 8.7; 22.6 | 2.8; 17.1 | 7.4; 21.7 |
| P | 0.033 | 0.000 | 0.075 | <0.001 | 0.641 | 0.133 | 0.033 | <0.001 | 0.007 | <0.001 |
| Blood Pressure (mmHg) | ||||||||||
| Systolic BP | ||||||||||
| Coeficient | 0.2 | 6.2 | 2.3 | 6.2 | −1.4 | −0.3 | 0.4375 | 5.4 | 3.1 | 7.6 |
| 95% CI | −6.4; 6.9 | −0.5; 12.8 | −4.4; 9.1 | −0.4; 12.8 | −8.3; 5.6 | −7.4; 6.8 | −6.4; 7.3 | −1.4; 12.3 | −3.6; 9.8 | 0.9; 14.3 |
| P | 0.944 | 0.068 | 0.488 | 0.066 | 0.693 | 0.940 | 0.898 | 0.117 | 0.353 | 0.027 |
| Diastolic BP | ||||||||||
| Coeficient | 1.3 | 6.1 | 1.0 | 3.6 | 2.3 | 1.9 | 1.8 | 5.9 | 2.3 | 5.4 |
| 95% CI | −4.0; 7.1 | 0.3; 11.8 | −5.0; 6.9 | −2.3; 9.4 | −4.0; 8.5 | −4.4; 8.3 | −4.4; 7.9 | −0.3; 12.0 | −3.9; 8.5 | −0.8; 11.6 |
| P | 0.654 | 0.040 | 0.745 | 0.227 | 0.473 | 0.542 | 0.570 | 0.061 | 0.470 | 0.088 |
| Glucose (mg/dL) | ||||||||||
| Coeficient | 4.9 | 0.1 | 4.9 | 10.6 | −5.1 | −0.6 | 4.2 | 2.3 | 1.3 | 2.9 |
| 95% CI | −0.8; 10.6 | −5.6; 4.7 | −0.1; 10.0 | 5.6; 15.7 | −10.9; 0.8 | −6.4; 5.2 | −1.8; 10.1 | −3.6; 8.3 | −4.7; 7.3 | −3.1; 8.9 |
| P | 0.089 | 0.983 | 0.055 | <0.001 | 0.087 | 0.838 | 0.165 | 0.433 | 0.657 | 0.341 |
| Triglycerides (mg/dL) | ||||||||||
| Coeficient | 28.4 | 52.3 | 36.6 | 38.8 | 3.7 | −23.1 | 14.2 | 56.7 | 31.7 | 56.4 |
| 95% CI | −2.9; 59.8 | 20.9; 83.7 | 4.1; 69.0 | 6.3; 71.3 | −30.8; 38.1 | −57.5; 11.4 | −16.7; 45.0 | 25.8; 87.6 | 0.5; 62.9 | 25.2; 87.7 |
| P | 0.075 | 0.002 | 0.028 | 0.020 | 0.832 | 0.184 | 0.360 | 0.001 | 0.046 | 0.001 |
| HDL-C (mg/dL) | ||||||||||
| Coeficient | −6.0 | −3.0 | −2.3 | −8.2 | −5.1 | 1.9 | −1.1875 | −4.9 | −5.3 | −9.4 |
| 95% CI | −14.5; 2.6 | −11.6; 5.5 | −10.6; 6.1 | −16.6; 0.1 | −13.2; 3.0 | −6.2; 10.0 | −9.4; 7.0 | −13.1; 3.3 | −13.2; 2.6 | −17.3; −1.5 |
| P | 0.167 | 0.477 | 0.586 | 0.053 | 0.213 | 0.644 | 0.773 | 0.237 | 0.182 | 0.021 |
| Adipokines | ||||||||||
| Adiponectin (μg/mL) | ||||||||||
| Coeficient | −4.6 | 4.3 | 0.3 | −1.1 | 2.0 | 1.9 | - | - | ||
| 95% CI | −12.9; 3.8 | −4.2; 12.8 | −8.7; 9.3 | −9.9; 7.8 | - | - | −6.9; 10.8 | −6.9; 10.7 | ||
| P | 0.274 | 0.317 | 0.950 | 0.809 | 0.656 | 0.667 | ||||
| Adiponectin (μg/mL/Kg) | ||||||||||
| Coeficient | −0.7 | −0.5 | −0.5 | −1.7 | −0.5 | −1.0 | - | - | ||
| 95% CI | −2.1; 0.6 | −1.8; 0.9 | −1.8; 0.7 | −2.9; −0.5 | - | - | −1.9; 0.9 | −2.3; 0.4 | ||
| P | 0.288 | 0.497 | 0.408 | 0.009 | 0.445 | 0.165 | ||||
| Leptin (μg/mL) | ||||||||||
| Coeficient | 7.3 | 16.0 | 4.3 | 10.0 | 4.9 | 2.0 | - | - | - | |
| 95% CI | 4.6; 10.0 | 13.2; 18.8 | −0.3; 9.0 | 5.4; 14.6 | -0.3; 10.2 | −3.2; 7.3 | ||||
| P | <0.001 | <0.001 | 0.069 | <0.001 | 0.067 | 0.441 | ||||
| Leptin (μg/mL/Kg) | ||||||||||
| Coeficient | 0.6 | 1.0 | 0.7 | 0.3 | 0.7 | 0.1 | - | - | - | - |
| 95% CI | 0.1; 1.2 | 0.4; 1.5 | 0.1; 1.3 | −0.3; 0.9 | 0.1; 1.2 | -0.4; 0.7 | ||||
| P | 0.048 | 0.001 | 0.037 | 0.341 | 0.032 | 0.699 | ||||
| Insulin resistance | ||||||||||
| Fasting insulin (mμ/mL) | ||||||||||
| Coeficient | 13.3 | 10.6 | - | - | −2.2 | −2.3 | 10.6 | 15.0 | 11.2 | 13.1 |
| 95% CI | 7.0; 19.6 | 4.3; 16.9 | −10.1; 5.6 | −10.1; 5.5 | 4.2; 17.0 | 8.6; 21.4 | 4.6; 17.9 | 6.4; 19.8 | ||
| P | <0.001 | 0.001 | 0.569 | 0.559 | 0.002 | <0.001 | 0.001 | <0.001 | ||
| HOMA-IR | ||||||||||
| Coeficient | 3.2 | 2.3 | - | - | −0.8 | −0.6 | 2.6 | 3.4 | 2.6 | 3.1 |
| 95% CI | 1.6; 4.9 | 0.7; 3.9 | −2.8; 1.1 | −2.5; 1.3 | 0.9; 4.3 | 1.7; 5.1 | 0.9; 4.3 | 1.3; 4.8 | ||
| P | <0.001 | 0.007 | 0.391 | 0.537 | 0.003 | <0.001 | 0.004 | 0.001 | ||
Values obtained through robust linear regression analysis, adjusted for gender, age, treatment (only chemotherapy or chemotherapy plus radiotherapy), and diagnoses (acute lymphoblastic leukemia or lymphoma). aThe referent was tertile 1. Abbreviations: MS Metabolic syndrome