Table 4.
Odds of use of Antipsychotics or Antidepressants at one time point given use of Antipsychotics or Antidepressants at the previous time point, covariates measured at the “previous” time point, N = 1406 observations
| Variables | Antipsychotics | Antidepressants | ||||||
|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Assessed at previous time point | ||||||||
| CDR sum of boxes | 1.04 (1.002; 1.07) | 0.036 | 0.97 (0.95; 0.995) | 0.020 | ||||
| GMHR | ||||||||
| Good | 1.25 (0.66; 2.37) | 0.498 | 0.98 (0.59; 1.63) | 0.934 | 0.63 (0.35; 1.12)3 | 0.111 | ||
| Fairly good | 1.11 (0.63; 1.98) | 0.715 | 1.29 (0.82; 2.02) | 0.273 | 0.92 (0.56; 1.51)8 | 0.745 | ||
| Poor | 1.53 (0.86; 2.72) | 0.151 | 1.62 (1.03; 2.56) | 0.038 | 1.34 (0.83; 2.16)5 | 0.229 | ||
| Very Poor | 1 | - | 1 | - | 1 | - | ||
| PSMS score | 1.03 (0.997; 1.06) | 0.073 | 0.96 (0.94; 0.98) | 0.001 | 0.94 (0.91; 0.97)2 | <0.001 | ||
| NPI Agitation sub-syndrome | 1.05 (1.03; 1.07) | <0.001 | 1.02 (0.997; 1.04)6 | 0.093 | 0.997 (0.98; 1.01) | 0.714 | ||
| NPI Psychosis sub-syndrome | 1.09 (1.06; 1.12) | <0.001 | 1.06 (1.03; 1.10)2 | 0.001 | 1.00 (0.98; 1.03) | 0.915 | 0.97 (0.95; 1.00)4 | 0.060 |
| NPI Affective sub-syndrome | 1.06 (1.03; 1.09) | <0.001 | 1.03 (0.999; 1.07)5 | 0.060 | 1.08 (1.05; 1.10) | <0.001 | 1.08 (1.05; 1.11)1 | <0.001 |
| NPI Apathy | 1.07 (1.03; 1.12) | <0.001 | 0.99 (0.96; 1.03) | 0.732 | ||||
| Assessed at baseline | ||||||||
| Age | 0.95 (0.93; 0.97) | <0.001 | 0.95 (0.93; 0.97)1 | <0.001 | 0.99 (0.98; 1.01) | 0.317 | 0.98 (0.97; 1.00)6 | 0.056 |
| Females | 0.56 (0.40; 0.80) | 0.001 | 0.64 (0.44; 0.93)4 | 0.019 | 1.38 (1.02; 1.87) | 0.035 | 1.33 (0.97; 1.82)7 | 0.078 |
| Education (<=10 years) | 0.97 (0.68; 1.39) | 0.865 | 0.88 (0.66; 1.17) | 0.385 | ||||
| Duration in NH (LN) | 1.21 (1.06; 1.40) | 0.007 | 1.21 (1.05; 1.40)3 | 0.011 | 0.98 (0.88; 1.09) | 0.654 | ||
| Nursing home size | 0.998 (0.993; 1.003) | 0.382 | 1.00 (0.998; 1.01) | 0.347 | ||||
| Type of nursing home unit | ||||||||
| RU | 1 | - | 1 | - | ||||
| REU | 0.57 (0.10; 3.41) | 0.539 | 1.03 (0.30; 3.51) | 0.959 | ||||
| SCU | 1.24 (0.78; 1.97) | 0.367 | 0.80 (0.55; 1.17) | 0.248 | ||||
| OU | 3.25 (0.63; 16.81) | 0.160 | 1.13 (0.28; 4.61)1 | 0.865 | ||||
RU Regular units
REU rehabilitation unit
SCU special care unit for people with dementia
OU other units
The relative importance of each covariate in the adjusted models is included with a number after the 95% CI; lowest number has highest importance