Table 3.
Cord blood cardiometabolic markers between randomised treatment groups
| Outcome | Lifestyle advice group | Standard care group | Estimated difference (95% CI) (unadjusted) | P value (unadjusted) | Estimated difference (95% CI) (adjusted)a | P value (adjusted) |
|---|---|---|---|---|---|---|
| Cholesterol (mmol/L) | 1.79 (0.71) | 1.80 (0.73) | 0.01 (–0.07, 0.09) | 0.858 | 0.01 (–0.07, 0.09) | 0.853 |
| CRPb,c mg/L | 0.30 (0.30, 0.30) | 0.30 (0.27, 0.30) | 1.16 (0.74, 1.82) | 0.513 | 1.09 (0.69, 1.72) | 0.701 |
| Glucosec (mmol/L) | 3.53 (1.38) | 3.53 (1.46) | 0.00 (–0.16, 0.17) | 0.968 | –0.00 (–0.16, 0.16) | 0.984 |
| HDL (mmol/L) | 0.63 (0.25) | 0.63 (0.25) | –0.01 (–0.03, 0.02) | 0.680 | –0.01 (–0.04, 0.02) | 0.548 |
| Insulinb,c (μIU/mL) | 10.04 (6.22, 14.93) | 9.41 (5.97, 14.75) | 1.06 (0.98, 1.14) | 0.142 | 1.07 (0.99, 1.15) | 0.085 |
| NEFAb,c (mmol/L) | 0.19 (0.13, 0.27) | 0.19 (0.13, 0.28) | 0.97 (0.91, 1.04) | 0.424 | 0.96 (0.90, 1.03) | 0.276 |
| Triglyceridesb,c (mmol/L) | 0.39 (0.27, 0.56) | 0.40 (0.26, 0.57) | 1.01 (0.94, 1.09) | 0.767 | 0.98 (0.91, 1.05) | 0.565 |
| LDL (mmol/L) | 1.06 (0.54) | 1.07 (0.58) | 0.01 (–0.05, 0.08) | 0.689 | 0.02 (–0.05, 0.08) | 0.639 |
| Adiponectin (μg/mL) | 22.35 (16.93, 28.61) | 22.28 (16.77, 28.74) | 1.00 (0.95, 1.05) | 0.945 | 1.00 (0.94, 1.05) | 0.897 |
| Leptin (ng/mL) | 13.06 (7.98, 20.95) | 13.13 (7.90, 21.97) | 0.98 (0.90, 1.07) | 0.607 | 0.98 (0.90, 1.07) | 0.701 |
aAdjustment for centre, parity, BMI category (stratification variables), Socio-Economic Indexes for Areas Index of Relative Socio-Economic Disadvantage quintile, smoking status, and maternal age at consent
bOutcomes were log-transformed; descriptives for these outcomes are median and interquartile range, and estimates are ratios of geometric means (approximately ratios of medians)
All other outcomes are mean and standard deviation, and estimates are differences of means
cOutcomes were modelled using Tobit regression due to presence of values above and/or below detection limits
CRP C-reactive protein, HDL high-density lipoprotein cholesterol, NEFA non-esterified fatty acids, LDL low-density lipoprotein cholesterol