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. 2017 Feb 14;7:42433. doi: 10.1038/srep42433

Figure 6. Systemic application of LS3 suppresses sound evoked activity from the mouse auditory midbrain.

Figure 6

Example eRF having a BF of 19.5 kHz and a minimum threshold of 42 dB SPL. LS3 was administered via a systemic injection (0.3 mg/kg I.P.), and sound evoked activity was observed to decrease over a period of several hours from 522 spikes at baseline to 41 spikes at 2 hrs. and 37 spikes at 5 hrs. (A). Mean (±SEM) sound evoked activity from 47 units from 5 CBA mice in which LS3 was systemically administered. We observed a steady decline in sound evoked activity over the course of 2 hours, which accounted for an 85% reduction in spikes within the eRF (B).