Figure 7. Systemic application of LS3 or paxilline does not alter hearing thresholds or suppress sound evoked activity of inputs to the inferior colliculus as measured with the auditory brainstem responses.

Mean ABR thresholds (±SEM) at baseline (blue) and 4 hours (red) post I.P. injection of either paxilline (left) or LS3 (right). No significant effect of either BK channel modulator was observed. Mean amplitude by intensity functions for peak 1 (P1) and 4 (P4) of the ABR at baseline (blue symbols) and 4 hrs. following systemic injection (red symbols) of paxilline or LS3. Neither BK channel modulator reduced auditory nerve (P1) or brainstem (P4) amplitudes.