Table 3.
Relative mRNA expression of PDGF-B and BMP-6 in the cortical defect area analyzed by qRT-PCR
| Groups (n = 3) | BMP-6 | PDGF-B | ||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 7 | Day 14 | Day 1 | Day 3 | Day 7 | Day 14 | |
| S | 1.20 ± 0.12 | 1.00 ± 0.13 | 1.01 ± 0.21 | 1.01 ± 0.11 | 1.07 ± 0.49 | 1.01 ± 0.19 | 1.01 ± 0.13 | 1.01 ± 0.14 |
| K | 1.36 ± 0.32 | 1.46 ± 0.53 | 1.46 ± 0.30 | 1.76 ± 0.13 | 0.74 ± 0.25 | 0.72 ± 0.36 | 0.92 ± 0.08 | 1.94 ± 0.51 |
| F | 2.05 ± 0.27 | 4.36 ± 0.14*,† | 2.34 ± 0.59* | 3.50 ± 0.17*,† | 1.08 ± 0.25 | 1.13 ± 0.20 | 1.03 ± 0.06 | 2.39 ± 0.56* |
| N | 5.18 ± 0.68*,†,‡ | 2.86 ± 0.28*,† | 4.82 ± 0.76*,†,‡ | 5.37 ± 0.84*,†,‡ | 4.68 ± 0.20*,†,‡ | 2.94 ± 0.33*,†,‡ | 2.31 ± 0.31*,†,‡ | 4.04 ± 0.80*,† |
Values represent the mean ± SD of three animals for each group. *P<0.05 versus groups S; †P<0.05 versus groups K; ‡P<0.05 versus groups F. BMP-6: Bone morphogenetic protein-6; PDGF-B: Platelet-derived growth factor-B; qRT-PCR: Quantitative real-time polymerase chain reaction; S: Saline; K: Empty nanocapsules; F: Free 15-Deoxy-△12,14-prostaglandin J2; N: 15-Deoxy-△12,14-prostaglandin J2 nanocapsules; SD: Standard deviation; mRNA: Messenger RNA.