Table 2. Prospective trials of anticholinergic drugs in the management of neurogenic bladder related to SCI.

Author, year	Active drugs compared	Active	Active SCI	ASIA	UDS methdology	Video UDS	Standardized terminology	Bladder diary	Symptom score	Multicenter
Kennelly et al.27	Transdermal oxybutynin initially 3.9 and 7.8 mg per day to oxybutynin final 7.8, 9.1 and 11.7 mg per day	24 Total 18 final	Xa	Yes	Not detailed	No	Yes	Yes	No	Yes
Amend et al.28	Group A: Tolterodine and oxybutynin 15 or 30 mg Group B: Trospium chloride 90 mg and tolterodine 4–8 mg Group C: Oxybutynin 30 mg and trospium chloride 45 or 90 mg	27	21	No	Detailed	Yes	Yes	Yes	No	No
Zahariou et al.30	Oxybutynin 5 mg 1x3 daily DDAVP (intranasal)+oxybutynin 5 mg 1x3 daily	11	11	No	N/A	N/A	No	No	No	No
George et al.31	Oxybutynin 5 mg Propantheline 15 mg Capsaicin 1 mm/1 in 30% ethanol in saline	18	X	Yes	Not detailed	No	No	Yes	No	No
Bennett et al.32	Oxybutynin XL 10 mg, increasing to 15, 20, 25 and 30 mg	39	10	No	N/A	N/A	No	No	No	No
O'Leary et al.34	Oxbutynin XL 10 mg, increasing to 30 mg (n=5)	10	10	Yes	Detailed	Yes	No	Yes	No	No
Pannek et al.35	Oxybutynin (oral) 4x5 mg per day Oxybutynin (oral) 4x5 mg per day+oxybutynin (intravesical) 3x15 mg per day dissolved in 15 ml solution	25	25	No	Detailed	No	No	Yes	No	No
Haferkamp et al.36	Oxybutynin (intravesical) 0.3 mg/kg increasing to 0.9 mg/kg	32	17	No	Detailed	Yes	Yes	No	No	No
Vaidyananthan et al.37	Oxybutynin 1–3x5.0 mg per day	7	7	No	N/A	N/A	No	No	No	No
Szollar and Lee38	Ditropan 1–3x5.0 mg per day diluted in 30 ml saline solution	13	13	No	Detailed	Yes	No	No	No	No
Singh and Thomas39	Oxybutynin (intravesical) 1x10.0 mg per day diluted in 30 ml solution	6	6	No	Detailed	Yes	No	No	No	No
O'Flynn and Thomas40	Oxybutynin (intravesical) 1x5.0 mg diluted in distilled water	15	12	No	Detailed	No	No	No	No	No
Prasad and Vaidyananthan41	Oxybutynin 3x5.0 mg per day dissolved in 10 ml boiled and cooled tap water	12	8	No	Detailed	No	No	No	No	No
Madersbacher et al.42	Intravesical oxybutynin 5 mg tab crushed into 30 cm3 water	13	13	Predates	No	No	Predates	No	Predates	No
Diokno and Lapides44b	Part 1: Oxybutynin 1x5.0 mg to Probanthine (oral) 1x15 mg OR probanthine (intravenous) 1x60 mg	8	5	Predates	No	No	No	No	No	No
	Part 2: Oxybutynin 2–3x5.0 mg per day to no medication	8	8	Predates	No	No	Predates	No	Predates	No
Bodner et al.43	'Verapamil (alone) 240SL Oxybutynin (alone) 5 mg Verapamil+oxybutyninb	14	14	Predates	No	Yes	Predates	No	Predates	No

Abbreviations: ASIA, American Spinal Injury Association Impairment Scale; N/A, not applicable; SCI, spinal cord injury; TCl, trospium chloride; tolt, tolterodine; UDS, urodynamic studies.

^aX=No information provided or could be obtained.

^bOnly parts 1 and 2 included patients with neurogenic bladder.