Table 1.

Changes in the expression of genes relevant to the Cell Junction pathway. Listed up- and down-regulated genes in the Test Sample (after coculture) divided by the normalized gene expression in the Control Sample (before coculture). Two-fold change is taken as significant.

Cells	Genes Over-Expressed	Genes Under-Expressed
FB after PNT2	CAV1,CAV2,CAV3,CDH1,CDH2,CLDN1 CLDN11,CLDN12,CLDN4,CLDN7,CLDN9 DLL1,DSC2,DSC3,DSG2,DSP,F11R,GJA1 GJA5,GJB1,GJB3,GJB4,GJB5,GJC2,ICAM1 ICAM2,ITGA1,ITGA4,ITGA5,ITGAV,ITGB1 ITGB3,ITGB4,ITGB5,ITGB6,JAM2,JUP,NOTCH1 NOTCH2,OCLN,PVRL2,PVRL3,TJP1,TJP3
PNT2 after FB	GJA1,ITGA5,JAM3,PVRL3	GJC3
FB after PC3	CDH1,CDH2,CLDN1,CLDN14,CLDN3,CLDN4 DSC2,DSC3,DSG2,ESAM,F11R,GJA1,GJB3 ICAM1,ITGB2,ITGB4,JUP,OCLN,PVRL1,TJP1	CAV1,CLDN10,CLDN11,CLDN16,CLDN17 CLDN18,CLDN2,CLDN6,DLL1,DSC1,DSG1 DSG3,DSG4,DST,GJA4,GJA5,GJA8,GJB6 GJD2,GJC3,ITGA2,ITGA4,ITGA7,ITGA8 ITGA9,JAM2,JAM3,PVRL3,TJP2,TJP3
PC3 after FB	CAV3,CDH1,CLDN1,CLDN10,CLDN11,CLDN17 CLDN19,CLDN3,CLDN5,CLDN6,CLDN7,CLDN8 CLDN9,DLL1,DSC1,DSG1,DSG3,DSG4,DSP GJA1,GJA3,GJA4,GJA5,GJA8,GJB1,GJB2,GJB3 GJB4,GJD2,ICAM2,ITGA1,ITGA2,ITGA4,ITGA5 ITGA7,ITGA8,ITGA9,ITGAL,ITGAM,ITGB2 ITGB3,ITGB6,JAM2,JAM3,JUP,NOTCH3 PVRL1,PVRL2,TJP3,HGDC	DSG2,ITGB4