Table 3.
Macro- and micro-vascular function.
| Variables | Baseline |
Change at 3 months |
Change at 12 months |
||||||
|---|---|---|---|---|---|---|---|---|---|
| RDT | Control | P | RDT | Control | P | RDT | Control | P | |
| Macro-vascular function | |||||||||
| AA strain (%) | 3.6 (2.2, 7.6) | 3.6 (2.6–5.2) | 0.977 | +0.8 (−1.0, 1.4) | +0.1 (−2, 2.7) | 0.881 | −0.0 (−2.6, 0.8) | +1.3 (−2.4, 3.0) | 0.260 |
| AA disten. (10−3 mmHg−1) | 0.66 (0.41–1.19) | 0.76 (0.42–0.87) | 0.798 | +0.06 (−0.15, 0.40) | +0.12 (−0.40, 0.61) | 0.976 | +0.02 (−0.24, 0.25) | +0.25 (−0.26, 0.38) | 0.455 |
| DA strain (%) | 8.0 (6.8–10.0) | 8.2 (4.8–9.6) | 0.711 | +1.0 (−2.2, 2.5) | +1.0 (−0.1, 1.3) | 1.000 | +0.2 (−1.5, 1.1) | −0.3 (−0.7, 1.5) | 0.664 |
| DA disten. (10−3 mmHg−1) | 1.44 (1.09–1.76) | 1.22 (1.06–1.31) | 0.262 | +0.34 (−0.37, 0.61) | +0.07 (−0.31, 0.77) | 0.928 | +0.16 (−0.14, 0.42) | +0.02 (0.00, 0.42) | 0.932 |
| Pulse wave velocity (m/s) | 9.61 (5.62–11.7) | 9.03 (6.73–19.66) | 0.466 | +0.87 (−0.65, 2.16) | +1.26 (−3.61, 10.86) | 0.815 | +1.49 (−0.09, 3.21)* | +0.36 (−2.51, 3.44) | 0.447 |
| AI (at 75 bpm) (%) | 4 (−7, 20) | 8 (−3, 17) | 0.921 | −3 (−10, 11) | −4 (−13, 17) | 0.831 | −2 (−9, 8) | +2 (−3, 15) | 0.341 |
| Micro-vascular function | |||||||||
| Ln RHI | 0.39 ± 0.21 | 0.56 ± 0.34 | 0.133 | +0.03 ± 0.24 | −0.13 ± 0.14 | 0.098 | −0.03 ± 0.21 | +0.00 ± 0.42 | 0.788 |
| Urine ACR (µg/mg) | 40 (10–139) | 32 (9–75) | 0.665 | +3 (−88, 42) | −2 (−17, 21) | 0.949 | +10 (−3, 199) | −0 (−26, 12) | 0.357 |
AA: ascending aorta; DA: descending aorta; AI: augmentation index; LnRHI: natural log of reactive hyperaemic index; ACR: albumin:creatinine; disten.: distensibility.
*
P < 0.05 (for within group change).