Table 4.
Unadjusted and adjusted hazard ratios for the risk of 1-year mortality of the patients according to each increment in category or score of 0.1 of the different frailty, comorbidity, or disability instruments
| Instrument | All patients (n=305)
|
Subgroup of patients aged 65–82 years (n=139)
|
Subgroup of patients aged ≥83 years (n=166)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | Adj* HR (95% CI) | P-value | HR (95% CI) | P-value | Adj* HR (95% CI) | P-value | HR (95% CI) | P-value | Adj* HR (95% CI) | P-value | |
| CFS-7 (per each category increment) | 3.789 (2.681–5.354) | <0.001 | 3.667 (2.590–5.194) | <0.001 | 3.871 (2.137–7.011) | <0.001 | 3.950 (2.124–7.343) | <0.001 | 3.550 (2.323–5.427) | <0.001 | 3.485 (2.276–5.337) | <0.001 |
| FI (per each 0.1 score increment) | 1.954 (1.644–2.323) | <0.001 | 1.918 (1.607–2.289) | <0.001 | 1.763 (1.310–2.371) | <0.001 | 1.812 (1.323–2.482) | <0.001 | 2.006 (1.618–2.486) | <0.001 | 1.981 (1.592–2.464) | <0.001 |
| FRAIL Scale (per each category increment) | 3.708 (2.347–5.857) | <0.001 | 3.570 (2.263–5.631) | <0.001 | 3.885 (1.714–8.805) | 0.001 | 3.818 (1.658–8.788) | 0.002 | 3.488 (2.012–6.046) | <0.001 | 3.515 (2.027–6.098) | <0.001 |
| CIRS-G (per each 4 point increment) | 1.799 (1.523–2.126) | <0.001 | 1.763 (1.486–2.091) | <0.001 | 1.891 (1.362–2.626) | <0.001 | 1.899 (1.352–2.667) | <0.001 | 1.710 (1.407–2.078) | <0.001 | 1.701 (1.390–2.083) | <0.001 |
| Comorbidity-D-FI (per each 0.1 score increment) | 1.719 (1.399–2.111) | <0.001 | 1.727 (1.392–2.144) | <0.001 | 1.759 (1.231–2.513) | 0.002 | 1.724 (1.184–2.511) | 0.005 | 1.660 (1.285–2.144) | <0.001 | 1.727 (1.311–2.274) | <0.001 |
| ADL-Katz (per each disability increment) | 1.543 (1.352–1.761) | <0.001 | 1.507 (1.316–1.726) | <0.001 | 1.405 (1.120–1.764) | 0.003 | 1.427 (1.122–1.813) | 0.004 | 1.585 (1.344–1.870) | <0.001 | 1.559 (1.317–1.845) | <0.001 |
| IADL/ADL-D-FI (per each 0.1 score increment) | 1.335 (1.219–1.462) | <0.001 | 1.321 (1.202–1.452) | <0.001 | 1.258 (1.081–1.465) | 0.003 | 1.264 (1.079–1.482) | 0.004 | 1.376 (1.226–1.545) | <0.001 | 1.364 (1.211–1.536) | <0.001 |
Note:
Cox proportional hazard model considering age, female gender, and the instrument, with respect to frailty, comorbidity, or disability.
Abbreviations: Adj, adjusted; ADL, basic activities of daily living; ADL-Katz, disability burden based on the six ADLs of the Katz index; CFS-7, Canadian Study on Health and Aging Clinical Frailty Scale; FI, frailty index; CIRS-G, Cumulative Illness Rating Scale for Geriatrics; Comorbidity-D-FI, Comorbidity domain of the frailty index; IADL, instrumental activities of daily living; IADL/ADL-D-FI, IADL/ADL domain of the frailty index; CI, confidence interval; HR, hazard ratio.