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Rate Constants for Reaction of α-Methylene-γ-lactones with Cysteine
| Compound | Rate Constant (M−1s−1)a |
|---|---|
| 195 | 1.7 |
| Elephantopin (192) | 43 |
| Iodoacetamide | 25 |
| Eupatundin (193) | ~42b |
| Vernolepin (194) | ~200b |
| N-ethylmaleimide | 3750 |
Reported second order rate constants with cysteine (2 equivalents) in aqueous buffer (pH = 7.4)
The kinetics for the addition of cysteine to 193 and 194 were nonlinear, so the rate constants were calculated from initial rates.
